:root{--paper:#f8f7f3;--white:#fff;--ink:#24332e;--muted:#66726b;--green:#173f38;--green-light:#e9efea;--line:#dedfd7;--orange:#a74d30;--orange-light:#f7eee5;--serif:Georgia,'Times New Roman',serif;--sans:Inter,-apple-system,BlinkMacSystemFont,'Segoe UI',sans-serif;--mono:'SFMono-Regular',Consolas,monospace}
*{box-sizing:border-box}html{scroll-behavior:smooth;scroll-padding-top:104px}body{margin:0;background:var(--paper);color:var(--ink);font-family:var(--sans);font-size:15px;line-height:1.65}a{color:inherit;text-decoration:none}button,input,select{font:inherit}button,a,input,select,summary{-webkit-tap-highlight-color:transparent}button{cursor:pointer}button:disabled{cursor:default}svg{width:20px;height:20px;fill:none;stroke:currentColor;stroke-width:1.6;stroke-linecap:round;stroke-linejoin:round;flex-shrink:0}button:focus-visible,a:focus-visible,input:focus-visible,select:focus-visible,summary:focus-visible{outline:3px solid #bf742f;outline-offset:4px}button{color:inherit}h1,h2,h3,h4,p{margin-top:0}h1,h2,h3{font-weight:500}h1{font-family:var(--serif);font-size:48px;line-height:1.13;letter-spacing:-1.5px}h2{font-family:var(--serif);font-size:30px;line-height:1.25;letter-spacing:-.7px}h3{font-size:18px;line-height:1.4}p{margin-bottom:18px}small{font-size:12px}ul{padding-left:22px}li+li{margin-top:9px}::selection{background:#d3e1d3}.sr-only{position:absolute;width:1px;height:1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap}.skip-link{position:fixed;top:-100px;left:16px;z-index:20;background:var(--green);color:white;padding:10px 18px}.skip-link:focus{top:8px}.topbar{height:86px;position:sticky;top:0;z-index:10;background:var(--paper);border-bottom:1px solid var(--line);display:flex;align-items:center;gap:32px;padding:0 30px}.brand{display:flex;gap:11px;align-items:center;min-width:233px;line-height:1.3;font-size:21px;letter-spacing:-.7px}.brand b{font-weight:600}.brand small{display:block;font-size:8px;letter-spacing:1.65px;margin-top:5px;color:var(--muted)}.brand-mark{display:grid;place-items:center;background:var(--green);color:var(--paper);width:38px;height:42px;border-radius:10px 10px 13px 13px}.brand-mark svg{width:24px;height:24px}.search{max-width:500px;width:100%;display:flex;align-items:center;gap:12px;color:var(--muted);border:1px solid var(--line);border-radius:7px;padding:9px 12px;background:#f0f0e9}.search input{min-width:0;width:100%;border:0;background:none;outline-offset:5px;font-size:12px;color:var(--ink)}.search input::placeholder{color:#6d766e}.search kbd{font-size:10px;white-space:nowrap;border:1px solid #d5d9cf;border-radius:3px;padding:0 4px}.edition{font-family:var(--serif);font-style:italic;font-size:13px;white-space:nowrap;margin-left:auto;color:var(--muted)}.icon-button{border:1px solid var(--line);background:transparent;border-radius:5px;width:38px;height:38px;display:grid;place-items:center}#menu-toggle{display:none}.app-shell{display:grid;grid-template-columns:252px minmax(0,1fr)}.sidebar{height:calc(100vh - 86px);position:sticky;top:86px;display:flex;flex-direction:column;padding:29px 21px 20px;border-right:1px solid var(--line);overflow-y:auto;scrollbar-width:thin}.nav-label,.eyebrow{font-family:var(--mono);font-size:10px;text-transform:uppercase;letter-spacing:1.65px;color:var(--muted)}.nav-label{display:block;margin:24px 12px 12px}.nav-label:first-child{margin-top:0}.nav-item{display:flex;align-items:center;gap:10px;font-size:13px;padding:9px 12px;margin:3px 0;border-radius:5px;color:#59675d}.nav-item svg{width:17px;height:17px}.nav-item:hover{background:#eeeee7}.nav-item.active{background:var(--green-light);color:var(--green);font-weight:600}.nav-item .nav-count{margin-left:auto;color:var(--muted);font-size:10px;font-family:var(--mono)}.nav-group{margin:15px 0}.nav-group-title{display:flex;gap:9px;align-items:center;font-size:12px;font-weight:600;margin:0 11px 7px}.dot{width:7px;height:7px;display:inline-block;background:var(--green);border-radius:50%;flex-shrink:0}.dot.cmp{background:#b09258}.dot.ddimer{background:#647c9d}.dot.troponin{background:#b97562}.nav-child{font-size:12px;line-height:1.4;display:block;border-left:1px solid var(--line);margin-left:14px;padding:7px 10px 7px 17px;color:var(--muted)}.nav-child:hover,.nav-child.active{color:var(--green);border-left:2px solid var(--green);padding-left:16px;background:#eef1e9}.sidebar-note{font-size:10px;font-weight:600;margin-top:auto;padding:28px 10px 0;color:var(--green)}.sidebar-note p{font-size:10px;font-weight:400;line-height:1.6;margin:9px 0 0;color:var(--muted)}.status-dot{display:inline-block;width:5px;height:5px;background:#557259;border-radius:50%;margin-right:5px}.workspace{min-width:0}main{max-width:1370px;margin:auto;min-height:calc(100vh - 170px);padding:39px 48px 64px}main:focus{outline:none}.page-top{display:flex;align-items:center;justify-content:space-between;gap:15px;margin-bottom:32px}.breadcrumb{font-size:11px;color:var(--muted)}.breadcrumb span{margin:0 9px;color:#a2a69c}.version{font-size:9px;font-family:var(--mono);color:var(--muted)}.hero{display:grid;grid-template-columns:minmax(0,1.25fr) minmax(250px,.9fr);gap:28px;padding:17px 0 42px;align-items:center}.hero .eyebrow{color:var(--orange);display:flex;align-items:center;gap:9px;font-size:10px}.hero .eyebrow:before{content:'';height:1px;width:24px;background:var(--orange)}.hero h1{font-size:clamp(42px,4.4vw,67px);letter-spacing:-2.5px;margin:20px 0}.hero h1 em{font-weight:400;color:var(--green)}.hero-copy{font-size:14px;line-height:1.85;color:var(--muted);max-width:435px}.button{display:inline-flex;align-items:center;justify-content:center;gap:16px;min-height:41px;background:var(--green);color:white;border:1px solid var(--green);border-radius:5px;padding:9px 18px;font-size:12px;font-weight:500}.button:hover{background:#28564a}.button.secondary{background:transparent;color:var(--green);border-color:#cdd5ca}.button.secondary:hover{background:var(--green-light)}.button svg{width:16px;height:16px}.hero-actions{display:flex;flex-wrap:wrap;gap:14px;margin-top:27px}.hero-meta{margin-top:23px;color:var(--muted);font-size:10px;display:flex;align-items:center;gap:8px}.hero-meta .dot{width:5px;height:5px;background:#8b9b84}.chemistry-map{position:relative;border:1px solid #d5d9cc;border-radius:8px;background:#eeefe7;padding:24px 22px;transform:rotate(-2deg);box-shadow:8px 9px 0 #e8e8df;max-width:390px;margin:6px auto 15px}.map-top{display:flex;justify-content:space-between;align-items:center;border-bottom:1px solid #cfd5c6;padding-bottom:12px;font-size:8px;letter-spacing:1.5px;font-family:var(--mono);color:var(--muted)}.map-top .dot{width:5px;height:5px}.fishbone{display:grid;grid-template-columns:repeat(3,1fr) 1.05fr;margin:32px 0 23px;text-align:center;font-family:var(--serif);color:var(--green);align-items:center}.fishbone div{display:flex;flex-direction:column}.fishbone b{font-size:29px;font-weight:400;padding:6px 5px}.fishbone b:first-child{border-bottom:1px solid #6b8372}.fishbone div+div{border-left:1px solid #6b8372}.fishbone .glucose{font-size:18px;border-left:1px solid #6b8372;height:92px;justify-content:center}.map-footer{border-top:1px solid #cfd5c6;padding-top:13px;display:flex;align-items:center;justify-content:space-between;font-size:9px;color:var(--muted)}.map-calcium{border:1px solid #bac8b5;padding:3px 9px;border-radius:4px;color:var(--green);font-family:var(--mono)}.map-caption{font-size:9px;line-height:1.6;margin:17px 0 0;color:var(--muted)}.section-heading{display:flex;align-items:center;justify-content:space-between;gap:14px;margin:34px 0 19px}.section-heading h2{font-size:24px;margin:0}.text-link{color:var(--green);font-size:11px;border-bottom:1px solid #b0bdae}.modules-grid{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:13px}.module-card{background:#fbfbf8;border:1px solid var(--line);border-radius:7px;padding:22px 18px 17px;transition:transform .15s,border-color .15s;display:flex;flex-direction:column;min-height:230px}.module-card:hover{transform:translateY(-3px);border-color:#899e8c}.card-icon{width:36px;height:36px;display:grid;place-items:center;background:var(--green-light);color:var(--green);border-radius:7px;margin-bottom:21px}.cmp .card-icon{background:#f1ecde;color:#806632}.ddimer .card-icon{background:#eaf0f4;color:#526d8e}.troponin .card-icon{background:#f4eae5;color:#a15f4e}.module-card h3{font-family:var(--serif);font-size:25px;margin-bottom:6px}.module-card p{font-size:11px;line-height:1.75;color:var(--muted);margin-bottom:19px}.card-bottom{margin-top:auto;display:flex;align-items:center;justify-content:space-between;font-family:var(--mono);font-size:9px;letter-spacing:.3px;color:var(--muted);padding-top:11px;border-top:1px solid var(--line)}.card-bottom svg{width:14px;height:14px;color:var(--green)}.split-section{display:grid;grid-template-columns:1.2fr 1fr;gap:28px;margin:35px 0}.learning-path{background:#eeefe7;border:1px solid var(--line);border-radius:7px;padding:26px}.learning-path h2{font-size:25px;margin:11px 0 8px}.learning-path>p{font-size:12px;color:var(--muted)}.path-step{display:grid;grid-template-columns:28px 1fr 18px;gap:10px;align-items:center;padding:15px 0;border-top:1px solid #d7dcd0}.path-step b{font-family:var(--mono);font-size:10px;font-weight:400;color:var(--muted)}.path-step span{font-size:12px}.path-step small{display:block;color:var(--muted);font-size:10px;margin-top:3px}.path-step svg{width:14px;height:14px}.pattern-links h2{font-size:25px;margin:3px 0 18px}.pattern-link{display:block;padding:15px 0;border-bottom:1px solid var(--line)}.pattern-link strong{font-size:12px;font-weight:500;display:flex;justify-content:space-between}.pattern-link small{font-size:11px;color:var(--muted);display:block;margin-top:3px}.pattern-link svg{width:15px;height:15px}.safety-note{display:flex;align-items:flex-start;gap:12px;border:1px solid #e2dccc;background:#f4f1e7;border-radius:5px;padding:17px 19px;font-size:11px;line-height:1.8;color:#70644d}.safety-note svg{width:17px;height:17px;margin-top:2px}.safety-note p{margin:0}.safety-note strong{font-weight:600;color:#5d513d}footer{display:flex;justify-content:space-between;gap:12px;flex-wrap:wrap;margin:0 48px;padding:21px 0;border-top:1px solid var(--line);font-size:9px;color:var(--muted)}footer a{border-bottom:1px solid var(--line)}.footer-dot{margin:0 8px}.page-intro{max-width:720px;margin-bottom:30px}.page-intro h1{margin:12px 0 15px}.page-intro p{color:var(--muted);font-size:14px}.filters{display:flex;gap:7px;flex-wrap:wrap;margin:25px 0}.filter{border:1px solid var(--line);background:none;border-radius:5px;padding:7px 13px;font-size:11px}.filter.active{background:var(--green);color:white;border-color:var(--green)}.results-note{font-family:var(--mono);color:var(--muted);font-size:10px;margin:20px 0}.article-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:15px}.article-card{border:1px solid var(--line);border-radius:6px;padding:22px 25px;background:#fcfcf9}.article-card:hover{border-color:#8ba18e}.article-card h2{font-size:24px;margin:13px 0 9px}.article-card p{font-size:12px;color:var(--muted);margin:0 0 16px}.article-card .range-preview{font-family:var(--mono);font-size:10px;color:var(--green);border-top:1px solid var(--line);padding-top:12px}.article-card .eyebrow{font-size:8px}.tag{display:inline-block;border-radius:3px;font-size:9px;padding:3px 7px;background:var(--green-light);color:var(--green);margin-right:5px}.article-layout{display:grid;grid-template-columns:minmax(0,760px) 195px;gap:44px;align-items:start}.article-content{min-width:0}.article-header{margin-bottom:30px}.article-header h1{margin:14px 0 15px;font-size:48px}.article-subtitle{font-size:16px;line-height:1.8;color:var(--muted)}.article-meta{display:flex;align-items:center;gap:12px;font-size:10px;color:var(--muted);flex-wrap:wrap;margin:22px 0}.article-tools{margin-left:auto;display:flex;gap:8px}.article-tools button{font-size:10px;display:inline-flex;align-items:center;gap:6px;background:transparent;border:1px solid var(--line);border-radius:4px;padding:5px 9px}.article-tools svg{width:12px;height:12px}.range-box{background:#eeefe7;border:1px solid #d3dacc;padding:18px 22px;border-radius:6px;margin-bottom:26px}.range-box .eyebrow{font-size:9px;margin-bottom:8px}.range-value{font-family:var(--mono);color:var(--green);font-size:18px;line-height:1.6}.range-note{font-size:11px;line-height:1.7;margin-top:6px;color:var(--muted)}.takeaways{border-left:3px solid var(--green);background:#edf1ea;padding:22px 25px;margin-bottom:38px}.takeaways h2{font-family:var(--sans);font-size:12px;letter-spacing:1px;text-transform:uppercase}.takeaways ul{font-size:14px;margin-bottom:0}.article-section{margin:37px 0;scroll-margin-top:110px}.article-section h2{font-size:29px;margin-bottom:19px}.article-section p,.article-section li{font-size:15px;line-height:1.95}.article-section li{padding-left:3px}.article-section .note{background:var(--orange-light);border-left:2px solid #ba8860;padding:15px 18px;font-size:13px;line-height:1.8;color:#785438;margin:23px 0}.section-sources{font-size:10px;color:var(--muted);margin:16px 0;display:flex;align-items:center;gap:7px;flex-wrap:wrap}.section-sources a{color:var(--green);text-decoration:underline;text-underline-offset:3px}.table-scroll{overflow-x:auto;border:1px solid var(--line);border-radius:5px;margin:22px 0;scrollbar-width:thin}.table-scroll:focus-visible{outline:3px solid #bf742f;outline-offset:2px}table{width:100%;border-collapse:collapse;font-size:12px;line-height:1.8;text-align:left;min-width:440px}th{background:#e9ede4;font-weight:600;color:var(--green)}td,th{padding:12px 15px;border-bottom:1px solid var(--line);vertical-align:top}tr:last-child td{border-bottom:0}tr:nth-child(even) td{background:#f2f3ec}.article-toc{position:sticky;top:119px;padding-left:20px;border-left:1px solid var(--line)}.article-toc .eyebrow{font-size:9px;margin:0 0 15px}.article-toc a{display:block;font-size:11px;line-height:1.6;margin:11px 0;color:var(--muted)}.article-toc a:hover{color:var(--green)}.toc-note{font-family:var(--serif);font-style:italic;color:#798573;font-size:14px;line-height:1.8;border-top:1px solid var(--line);margin-top:25px;padding-top:18px}.case-box{border:1px solid #ccd7c7;border-radius:7px;padding:27px;background:#f0f3eb;margin:35px 0}.case-box h2{font-size:27px;margin:12px 0 17px}.case-box .case-stem{font-size:14px;line-height:1.85}.case-box .question{font-weight:600;font-size:13px;margin:20px 0}details{border-top:1px solid #ccd7c7;padding-top:15px}summary{font-size:12px;cursor:pointer;color:var(--green);font-weight:600;padding:6px 0}details .answer{font-size:14px;line-height:1.9;padding-top:16px;margin:0}.article-references{border-top:1px solid var(--line);padding-top:27px;margin-top:35px}.article-references h2{font-size:24px}.article-references li{font-size:11px;line-height:1.8;margin:15px 0;padding-left:4px;overflow-wrap:anywhere}.article-references a{color:var(--green);text-decoration:underline;text-underline-offset:3px}.article-references span{display:block;color:var(--muted)}.article-next{display:flex;justify-content:space-between;gap:20px;align-items:center;border-top:1px solid var(--line);padding-top:24px;margin-top:35px;font-size:12px}.source-group{margin:35px 0}.source-group h2{font-size:27px}.source-row{padding:17px 0;border-bottom:1px solid var(--line)}.source-row a{color:var(--green);font-size:13px;text-decoration:underline;text-underline-offset:3px}.source-row small{display:block;color:var(--muted);margin-top:5px}.source-page{max-width:850px}.empty-state,.loading{border:1px solid var(--line);padding:40px;border-radius:7px;max-width:700px;margin:30px 0}.empty-state h2{font-size:28px}.empty-state p{color:var(--muted);font-size:14px}.case-list{max-width:850px}.case-list .case-box{margin-top:18px}.case-link{display:inline-block;font-size:10px;color:var(--green);margin-top:16px;text-decoration:underline;text-underline-offset:3px}.no-script{margin:30px;padding:20px;background:var(--orange-light)}
@media(min-width:1600px){main{padding-top:44px}.hero{gap:55px}.hero h1{font-size:72px}}
@media(max-width:1200px){.edition{display:none}.topbar{gap:20px}.app-shell{grid-template-columns:224px minmax(0,1fr)}.brand{min-width:203px}.sidebar{padding-left:14px;padding-right:14px}main{padding:30px 30px 50px}.hero{grid-template-columns:1.2fr 1fr;gap:20px}.hero h1{font-size:49px}.chemistry-map{padding:19px 15px}.modules-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.module-card{min-height:205px}.module-card .card-icon{margin-bottom:14px}.article-layout{grid-template-columns:minmax(0,1fr) 165px;gap:26px}.article-header h1{font-size:42px}.article-toc{padding-left:15px}footer{margin:0 30px}}
@media(max-width:1000px){.hero{grid-template-columns:1fr}.chemistry-map{display:none}.hero h1{font-size:58px}.hero-copy{max-width:510px}.split-section{grid-template-columns:1fr}.article-layout{grid-template-columns:1fr}.article-toc{display:none}.article-grid{grid-template-columns:1fr}.brand{min-width:203px}.hero{padding-bottom:25px}}
@media(max-width:720px){.topbar{height:76px;padding:0 18px;gap:12px;flex-wrap:wrap}.brand{min-width:0;font-size:19px;margin-right:auto}.brand small{font-size:7px;letter-spacing:1.1px}.brand-mark{width:32px;height:36px}.search{order:3;position:absolute;top:76px;left:0;max-width:none;border-radius:0;border-width:0 0 1px;padding:12px 19px;background:var(--paper);height:48px}.search input{font-size:12px}.search kbd{display:none}#menu-toggle{display:grid}.app-shell{display:block;margin-top:48px}.sidebar{position:fixed;left:0;top:124px;height:calc(100dvh - 124px);width:min(300px,85vw);background:var(--paper);z-index:9;display:none;box-shadow:10px 0 35px #24332e20;padding:23px}.sidebar.open{display:flex}main{padding:25px 21px 45px}.page-top{margin-bottom:20px}.breadcrumb{font-size:10px}.version{display:none}.hero{padding:9px 0 25px}.hero h1{font-size:49px;letter-spacing:-2px}.hero .eyebrow{font-size:9px;letter-spacing:1px}.hero-copy{font-size:13px}.hero-actions{gap:10px;margin-top:22px}.button{font-size:11px;padding:10px 14px}.hero-meta{font-size:9px;flex-wrap:wrap}.section-heading{margin-top:23px}.section-heading h2{font-size:23px}.module-card{padding:19px 15px;min-height:222px}.module-card h3{font-size:24px}.module-card p{font-size:11px}.card-bottom{font-size:8px}.modules-grid{gap:10px}.learning-path{padding:23px}.split-section{margin:25px 0;gap:25px}.safety-note{font-size:10px;padding:15px}.article-header h1,.page-intro h1{font-size:39px;letter-spacing:-1px}.article-subtitle{font-size:14px}.article-section h2{font-size:26px}.article-section p,.article-section li{font-size:14px;line-height:1.95}.article-section{scroll-margin-top:145px}.article-tools{margin-left:0}.takeaways{padding:20px}.takeaways ul{font-size:13px}.range-value{font-size:16px}.case-box{padding:23px 19px}.case-box h2{font-size:25px}footer{margin:0 21px;font-size:9px;line-height:1.9}html{scroll-padding-top:145px}.article-card{padding:20px}.page-intro{margin-bottom:22px}.filters{gap:6px}.filter{font-size:10px;padding:7px 11px}}
@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}*{transition:none!important;animation:none!important}}
@media print{body{background:white;color:#111;font-size:11pt}.topbar,.sidebar,.page-top,.article-toc,footer,.article-tools,.article-next,.skip-link,.hero-actions,.filters{display:none!important}.app-shell,.article-layout{display:block;margin:0}main{padding:0;max-width:none}h1{font-size:28pt}.article-header h1{font-size:28pt}.article-section h2{font-size:20pt}.article-section p,.article-section li{font-size:11pt;line-height:1.6}a{text-decoration:underline}.table-scroll{overflow:visible}table{min-width:0;font-size:10pt}.article-section,table,.case-box{break-inside:auto}h2,h3{break-after:avoid}details::details-content{content-visibility:visible;height:auto}details .answer{display:block}.takeaways,.case-box,.range-box{background:#f5f5f5}.source-row a,.article-references a{overflow-wrap:anywhere}.source-row a:after,.article-references a:after{content:' (' attr(href) ')';font-size:8pt}.modules-grid,.article-grid{grid-template-columns:repeat(2,1fr)}}
